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KMID : 0616120120430040338
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 4 p.338 ~ p.344
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Screening of Herbal Medicines from China and Vietnam with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (VIII)
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Choi So-Jin
Song Yoo-Jin
Kim Young-Sook
Kim Joo-Hwan
Hang Sun
Bach Tran The
Kim Jin-Sook
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Abstract
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Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 62 herbal edicines from China and Vietnam have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 5 herbal medicines (IC50<5 μg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Albizia odoratissima (twigs and leaves), Rhododendron spinuliferum (twigs and leaves), Dioscorea cirrhosa (stems and leaves), Illicium verum (stems and leaves) and Aglaia perviridis (stems and leaves), showed more potent inhibitory activity (approximately 16-26 fold) than the positive control aminoguanidine (IC50=76.47 μg/ml).
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KEYWORD
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Advanced glycation end products (AGEs) , Diabetic complications , Herbal medicines
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